THE HYPOXIA INDUCIBLE CELL DEATH GENE BNIP3 IS MUTATED IN MALIGNANT ASTROCYTIC TUMORS
Supporting the significance of these findings are observations that many primary patient glioblastoma samples have low or absent Caspase-8 expression levels.īIO 2. Our studies have confirmed that Caspase-8 levels can influence the requirement for mitochondrial involvement in death receptor apoptotic signaling in glioma cells.
These cells were used to explore molecular factors determining the necessity for mitochondrial amplification of death receptor signaling. In the present study we generated panels of clonal transfectants overexpressing various levels of Bcl-2 in two parental glioma cell lines. Our earlier work has demonstrated that glioma cells may either employ mitochondrial independent or dependent death receptor-induced apoptotic pathways, characteristic of cells termed type I and type II respectively. Elucidating apoptosis signaling pathways may assist in designing better adjuvant therapies. The majority of high-grade glioma patients die within a several years of diagnosis. Hawkins Department of Haematology and Oncology, Royal Children’s Hospital, Parkville, Australia CASPASE-8 LEVELS DETERMINE SIGNALLING PATHWAYS USED IN DEATH LIGAND-INDUCED GLIOMA CELL APOPTOSISĭavid M.
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